SrasV1, Main, Exploration, bibRecord, 004107

siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

Identifieur interne : 004107 ( Main/Exploration ); précédent : 004106; suivant : 004108

siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

Auteurs : Yuki Naito [Japon] ; Kumiko Ui-Tei [Japon] ; Toru Nishikawa [Japon] ; Yutaka Takebe [Japon] ; Kaoru Saigo [Japon]

Source :

Nucleic Acids Research [ 0305-1048 ] ; 2006.

RBID : ISTEX:0191DEE6E0B31171F5A8593BE29AE12B41EF6B99

Descripteurs français

KwdFr :
- ARN viral (), Agents antiVIH (), Antiviraux (), Interférence par ARN, Internet, Logiciel, Petit ARN interférent (), Séquence conservée, Séquence nucléotidique, Variation génétique, Virus à ARN (génétique).
MESH :
- génétique : Virus à ARN.
- ARN viral, Agents antiVIH, Antiviraux, Interférence par ARN, Internet, Logiciel, Petit ARN interférent, Séquence conservée, Séquence nucléotidique, Variation génétique.

English descriptors

KwdEn :
- Anti-HIV Agents (chemistry), Antiviral Agents (chemistry), Base Sequence, Conserved Sequence, Genetic Variation, Internet, RNA Interference, RNA Viruses (genetics), RNA, Small Interfering (chemistry), RNA, Viral (chemistry), Software.
MESH :
- chemical , chemistry : Anti-HIV Agents, Antiviral Agents, RNA, Small Interfering, RNA, Viral.
- genetics : RNA Viruses.
- Base Sequence, Conserved Sequence, Genetic Variation, Internet, RNA Interference, Software.

Abstract

siVirus (http://siVirus.RNAi.jp/) is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.

Url:

https://api.istex.fr/ark:/67375/HXZ-6BLM1M9S-X/fulltext.pdf

DOI: 10.1093/nar/gkl214

Affiliations:

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<front><div type="abstract" xml:lang="en">siVirus (http://siVirus.RNAi.jp/) is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.</div>
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siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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